P52561-B21 - HPE ProLiant DL380 Gen11 5416S NC 8SFF Server

HPE P52561-B21 — ProLiant DL380 Gen11 1P Xeon Gold 5416S (16-core) NC 8×SFF, 32GB, MR408i-o, 800W

What it is

An HPE ProLiant DL380 Gen11 2U rack server pre-configured as a scalable enterprise workhorse.
P52561-B21 is a Network Choice (NC) build with a single Intel Xeon Gold 5416S CPU, 8× SFF hot-swap bays, 32GB DDR5, and an HPE MR408i-o Gen11 storage controller. It’s a strong “starter DL380 Gen11” for virtualization and general compute, with room to grow into dual-socket, higher RAM, and richer storage later.

Why buyers pick P52561-B21 (plain English)

• Balanced Gold-tier compute to start
  A 16-core Xeon Gold gives a noticeable step up from Silver-class CPUs for mixed enterprise workloads.

• 8×SFF front bay layout
  Great for SSD-heavy deployments in a standard 2U footprint.

• Network Choice flexibility
  You pick the NIC strategy you want (OCP 3.0 / PCIe), so it fits your standard uplink speeds.

• MR408i-o controller included
  A proper hardware RAID foundation for SAS/SATA/NVMe-ready builds.

• Gen11 platform longevity
  DDR5, PCIe Gen5, iLO 6, and current ProLiant security/ops stack.

60-second spec box (P52561-B21)

Processor

• 1 × Intel Xeon Gold 5416S

• 16 cores / 32 threads, 2.0 GHz base (turbo up to ~4.0 GHz class)

• Dual-socket capable chassis (add a 2nd CPU later)

Memory

• 32 GB DDR5 Registered (1 × 32 GB RDIMM)

• Large Gen11 DIMM headroom for expansion

Drive bays / storage

• 8 × 2.5" SFF hot-swap bays (front)

• Ships without drives (configure to workload)

• HPE MR408i-o Gen11 x8 OCP storage controller with cache + battery support

Networking

• Network Choice (NC) configuration

• OCP 3.0 / PCIe NIC options for 1/10/25Gb builds

Expansion

• PCIe Gen5 slots for accelerators, high-speed storage, or extra NICs

Power

• 1 × 800W Flex Slot Platinum hot-plug PSU

• Supports a 2nd PSU for redundancy

Form factor

• 2U rack-mount DL380 Gen11 chassis

Included / not included

• No HDD/SSD

• No OS (BTO-ready)

Where it fits (and when to choose something else)

Perfect for:

• Virtualization hosts and cluster nodes

• General compute, databases, line-of-business apps

• SSD-dense 2U builds using 8×SFF

Choose something else if:

• You want more cores per socket out of the box → higher-core Xeon Gold starter SKUs

• You need a smaller footprint → DL360 Gen11 (1U)

• You need LFF bays for big HDD capacity → DL380 Gen11 LFF models

• You need heavier GPU configs → DL380 Gen11 GPU-optimized / DL380a

TL;DR

P52561-B21 is a strong DL380 Gen11 starter build:
1× Xeon Gold 5416S (16-core), 32GB DDR5, MR408i-o storage controller, 8×SFF hot-swap chassis, Network Choice NIC flexibility, and an 800W Platinum PSU — ideal as a scalable enterprise compute node.