P52560-B21 - HPE ProLiant DL380 Gen11 4410Y MR408I-O NC 8SFF Server

HPE P52560-B21 — ProLiant DL380 Gen11 1P Xeon Silver 4410Y (12-core) NC 8×SFF, 32GB, MR408i-o, 800W

What it is

An HPE ProLiant DL380 Gen11 2U rack server pre-configured as a reliable, scalable enterprise workhorse.
P52560-B21 is a Network Choice (NC) build with a single Intel Xeon Silver 4410Y CPU, 8× SFF hot-swap bays, 32GB DDR5, and an HPE MR408i-o Gen11 storage controller. It’s a practical “starter DL380 Gen11” for virtualization or general compute, with room to grow into more RAM, drives, faster NICs, or a second CPU later.

Why buyers pick P52560-B21 (plain English)

• DL380 Gen11 platform at a sensible starting point
  You get Gen11 security, iLO 6, DDR5, and PCIe Gen5 in a balanced config.

• 12-core Xeon Silver for everyday enterprise workloads
  A strong fit for virtualization clusters, app servers, and mixed workloads without paying for high-core Gold tiers.

• 8×SFF front bay layout
  Great for SSD-heavy builds and fast storage in a standard 2U chassis.

• Network Choice flexibility
  You choose the NIC/uplink strategy you want — not locked into one onboard setup.

• MR408i-o storage controller included
  Hardware RAID/SAS/SATA/NVMe-ready foundation for real-world storage configs.

60-second spec box (P52560-B21)

Processor

• 1 × Intel Xeon Silver 4410Y

• 12 cores / 24 threads, 2.0 GHz base (turbo up to ~3.9 GHz class)

• Dual-socket capable chassis (add a 2nd CPU later)

Memory

• 32 GB DDR5 Registered (1 × 32 GB RDIMM)

• Big Gen11 memory headroom for expansion

Drive bays / storage

• 8 × 2.5" SFF hot-swap bays (front)

• Ships without drives (configure to workload)

• HPE MR408i-o Gen11 x8 OCP storage controller with cache + battery support

Networking

• Network Choice (NC) configuration

• OCP 3.0 / PCIe NIC options for 1/10/25Gb builds

Expansion

• PCIe Gen5 slots for accelerators, high-speed storage, or extra NICs

Power

• 1 × 800W Flex Slot Platinum hot-plug PSU

• Supports a 2nd PSU for redundancy

Cooling / chassis

• Standard DL380 Gen11 fan set

• 2U rack-mount form factor

Included / not included

• No HDD/SSD

• No OS (BTO-ready)

Where it fits (and when to choose something else)

Perfect for:

• Virtualization hosts and cluster nodes

• General compute, databases, line-of-business apps

• SSD-dense 2U builds using 8×SFF bays

Choose something else if:

• You want more cores per socket out of the box → step up to a Xeon Gold starter SKU

• You need a smaller footprint → DL360 Gen11 (1U)

• You need LFF bays for large HDD capacity → DL380 Gen11 LFF models

• You need heavier GPU support → DL380 Gen11 GPU-optimized / DL380a variants

TL;DR

P52560-B21 is a balanced DL380 Gen11 starter build:
1× Xeon Silver 4410Y (12-core), 32GB DDR5, MR408i-o storage controller, 8×SFF hot-swap chassis, Network Choice NIC flexibility, and an 800W Platinum PSU — ideal as a scalable enterprise compute node.

HPE ProLiant DL380 Gen11 4410Y 2.0GHz 12-core 1P 32GB-R MR408i-o NC 8SFF 800W PS Server

Are you looking for a dual-socket scalable server solution to power data analytics or hybrid cloud workloads? The HPE ProLiant DL380 Gen11 server is a scalable 2U 2P solution that delivers exceptional compute performance, memory density with scalability and high-speed data transfer rate to run your most demanding applications. Powered by 4th and 5th Gen Intel ^® Xeon ^® Scalable Processors with up to 64 cores, 8 TB of memory, and 20 EDSFF drive as well as increased memory bandwidth and high-speed PCIe Gen5 I/O, the HPE ProLiant DL380 Gen11 server is a perfect solution for software-defined storage, video transcoding, and virtualized apps. The HPE ProLiant DL380 Gen11 server is engineered to optimize IT with a cloud operating experience, built-in security, and optimized performance for workloads to drive your business forward.

HPE ProLiant DL380 Gen11 8 SFF server with one Intel ^® Xeon ^® Silver 4410Y processor, 32 GB DDR5 RDIMM memory, Broadcom MR408i-o storage controller, and one HPE 800W Flex Slot Platinum Hot Plug Power Supply

Powered by the 4th and 5th Gen Intel ^® Xeon ^® Scalable Processors with next-generation technology that support up to 64 cores at 350W and 16 DIMMs for DDR5 memory at speeds up to 5600 MHz.

Support for up to 8 TB total DDR5 memory with 16 DIMM channels per processor delivers increased performance, lower power requirements, and High Bandwidth Memory (HBM) support.

Support for PCIe Gen5, resulting in improved bandwidth, advanced data transfer rates, and higher network speeds from the PCIe Gen5 serial expansion bus.

Includes the new HPE Integrated Lights-Out 6 (iLO 6) server management software that enables you to securely configure, monitor, and update your HPE ProLiant Gen11 servers seamlessly, from anywhere.

Supports hot-pluggable, high-availability RAID M.2 boot options.

Supports up to 8 single wide (SW) or 3 double wide (DW) GPUs to accelerate graphic intense workloads.

Intuitive Cloud Operating Experience: Simple, Self-service, and Automated

• HPE ProLiant DL380 Gen11 servers are engineered for your hybrid world. HPE ProLiant DL380 Gen11 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.
• Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.
• Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management reducing tasks and shortening maintenance windows.
• These experiences are engineered and built into all HPE ProLiant Gen11 servers, whether purchased as physical servers or consume as-a-service using HPE GreenLake as your compute and storage demands grow.
• Simplify and secure server management from edge to cloud with HPE GreenLake for Compute Ops Management. HPE GreenLake for Compute Ops Management is an as-a-service compute management experience that delivers greater simplicity, agility, and speed across your entire compute landscape, globally.

Trusted Security by Design: Uncompromising, Fundamental, and Protected

• The HPE ProLiant DL380 Gen11 server utilizes the HPE Silicon Root of Trust, HPE’s fundamental approach to security that provides zero-trust architecture at the silicon level and ensures all server essential firmware is free from malware or compromised code.
• The server, powered by 4th and 5th Gen Intel ^® Xeon ^® Scalable Processors, adds hardware and software-assisted security features, including Intel ^® Software Guard Extensions and Intel ^® Boot Guard, which secure the server hardware foundation on which critical apps run and better protect data in memory.
• HPE ProLiant Gen11 servers continuously protect healthy servers by providing rapid detection of security-compromised servers, even to the point of not allowing them to boot if it identifies and contains malicious code, and secure servers at the edge with IDevID certificates installed by default.
• HPE ProLiant servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of operating system, application and data connections, providing the fastest path to bring a server back online and into normal operations.
• From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Gen11 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements that are built into our DNA.

Optimized Performance for your Workloads: Accelerated, Open, and Efficient

• The HPE ProLiant DL380 Gen11 server is an excellent choice for compute and data storage demanding workloads (AI, ML, telco, DB analytics, VDI, containers) requiring maximum core count, GPU capabilities, and network and I/O bandwidth.
• Harness major computer performance. The HPE ProLiant DL380 Gen11 server is powered by 4th and 5th Gen Intel ^® Xeon ^® Scalable Processors with next-generation technology that supports up to 64 cores per processor, 350W, and up to 8 TB of memory.
• The HPE ProLiant DL380 Gen11 server provides advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 2 x16 PCIe Gen5 and 2 OCP slots to improve I/O throughput and reduce latency.
• It provides 16 DIMM channels per processor for up to 8 TB total DDR5 memory with increased memory bandwidth and performance, and lower power requirements.
• It provides real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs.

Available in an As-a-Service Experience

• The HPE ProLiant DL380 Gen11 server is supported by HPE GreenLake to simplify IT infrastructure management across your entire hybrid estate. With 24x7 monitoring and management, our experts do the heavy lifting to manage your environment with services built into consumption-based solutions.
• Hewlett Packard Enterprise provides customers with choices in how they acquire and consume IT beyond traditional financing and leasing, offering options that free trapped capital, accelerate infrastructure updates, and provide on-premises pay-per-use consumption with HPE GreenLake.