P43331-B21 - HPE 64GB 2RX4 PC5-4800B-R SMART Memory Kit

HPE P43331-B21 — 64GB (1×64GB) DDR5-4800 Registered ECC Smart Memory (Gen11)

What it is

P43331-B21 is an HPE Smart Memory RDIMM for ProLiant Gen11 servers.
It’s a 64GB DDR5 Registered ECC module running at 4800 MT/s, built and qualified by HPE for Gen11 platforms. Think “the standard 64GB DDR5 RDIMM you use to scale DL360/DL380 Gen11 and similar systems.”

Why buyers pick P43331-B21 (plain English)

• Big, clean capacity jump per slot
  64GB sticks are a fast way to scale memory without eating all your DIMM slots.

• Server-grade reliability
  Registered ECC memory is built for uptime and data integrity in 24×7 workloads.

• HPE-qualified Smart Memory
  Avoids compatibility surprises and enables proper performance/health reporting on ProLiant Gen11.

• Great for virtualization growth
  Lets you add RAM in meaningful chunks as VM density increases.

60-second spec box (P43331-B21)

Capacity

• 64 GB

Module type

• DDR5 RDIMM (Registered DIMM)

Speed / standard

• DDR5-4800 (PC5-38400 class)

Rank / organization

• Dual Rank (2R×4)

ECC / reliability

• ECC Registered (enterprise/server-grade)

Voltage

• 1.1V

Pins / form factor

• 288-pin DIMM

Target platforms

• HPE ProLiant Gen11 and other HPE systems that specify DDR5-4800 RDIMM Smart Memory

Where it fits (and when to choose something else)

Perfect for:

• Scaling RAM in Gen11 ProLiant servers

• Virtualization, database, analytics, and general enterprise compute

• Consolidation projects where memory per host matters

Choose something else if:

• Your server requires LRDIMMs instead of RDIMMs

• You need different capacity steps → 32GB / 128GB Gen11 DDR5 RDIMMs

• You’re on Gen10/Gen10+ (DDR4 platform) → use DDR4 Smart Memory instead

TL;DR

P43331-B21 is HPE’s 64GB DDR5-4800 ECC Registered Smart Memory RDIMM for Gen11 servers: a platform-qualified 64GB stick for scaling ProLiant Gen11 memory confidently and efficiently.