HPE P52534-B21 — ProLiant DL380 Gen11 CTO (Configure-to-Order) Server (Network Choice)
What it is
P52534-B21 is an HPE ProLiant DL380 Gen11 CTO (Configure-to-Order) server SKU.
That means it’s the base chassis/platform that you customize with your own CPU(s), memory, storage/backplane, RAID/HBA, NIC/OCP card, power supplies, rails, and OS as needed.
Why buyers pick P52534-B21 (plain English)
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Build it exactly the way you want
Perfect when you don’t want a fixed “factory bundle.” -
DL380 Gen11 = the 2U workhorse platform
Great for virtualization, storage-heavy builds, and general enterprise compute. -
Flexible networking (Network Choice)
Choose the right NIC speed and port type for your environment (1/10/25Gb, etc.). -
Room to expand
DL380 gives more drive and PCIe flexibility than 1U models.
60-second spec box (P52534-B21)
Server model
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HPE ProLiant DL380 Gen11 (2U)
SKU type
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CTO (Configure-to-Order) base system
Platform generation
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Gen11 (DDR5 + Intel Xeon Scalable)
Networking
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Network Choice (NC) — select NIC/OCP separately
Storage
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Drive bays/backplane chosen during config (SFF / LFF / NVMe options depending on build)
Memory
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DDR5 RDIMM Smart Memory (selected during config)
Power
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Flex Slot hot-plug PSUs (chosen during config)
TL;DR
P52534-B21 is a DL380 Gen11 CTO base server SKU — you customize it into the exact DL380 build your customer needs.
- Product Description: HPE ProLiant DL380 Gen11 8SFF NC CTO Server.
- Form Factor: 2U rack-mountable.
- Processor Support: Up to two 4th or 5th Gen Intel Xeon Scalable processors with up to 64 cores each (processors are sold separately).
- Processor Socket: FCLGA4677.
- Chipset: Intel C741.
- Memory Slots: 32 DIMM slots.
- Maximum Memory: Up to 8 TB of DDR5 memory (with 16 DIMM channels per processor).
- Memory Speed: Supports DDR5 memory up to 4800 MT/s.
- Drive Bays: 8 hot-pluggable 2.5-inch (SFF) drive bays for SAS, SATA, or NVMe drives.
- Storage Controller: Includes an embedded software RAID controller with 14 SATA ports (12 accessible). It also supports optional HPE modular Smart Array and PCIe plug-in controllers.
- Hard Drives: No hard drives are included in the base chassis.
- PCIe Expansion: Three standard PCIe Gen5 slots are included in the primary riser, with options to add more.
- FlexibleLOM: Two FlexibleLOM slots are available for optional OCP 3.0 network adapters.
- Network Controller: None embedded. Requires an optional OCP 3.0 or stand-up network adapter.
- Management: Includes HPE Integrated Lights-Out 6 (iLO 6) for secure remote management.
- Security: Features a Silicon Root of Trust, Secure Recovery, and TPM 2.0 standard on the motherboard.
- Power Supply: Does not include a power supply. Supports up to two redundant, hot-plug Flexible Slot power supplies (sold separately).
- Cooling: Includes four standard fans.
P52534-B21 - HPE ProLiant DL380 Gen11 8SFF NC CTO Server is for Configure-to-order Server build projects only and cannot be ordered separately.

Intuitive Cloud Operating Experience: Simple, Self-service, and Automated
- HPE ProLiant DL380 Gen11 servers are engineered for your hybrid world. HPE ProLiant DL380 Gen11 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.
- Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.
- Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management reducing tasks and shortening maintenance windows.
- These experiences are engineered and built into all HPE ProLiant Gen11 servers, whether purchased as physical servers or consume as-a-service using HPE GreenLake as your compute and storage demands grow.
- Simplify and secure server management from edge to cloud with HPE GreenLake for Compute Ops Management. HPE GreenLake for Compute Ops Management is an as-a-service compute management experience that delivers greater simplicity, agility, and speed across your entire compute landscape, globally.
Trusted Security by Design: Uncompromising, Fundamental, and Protected
- The HPE ProLiant DL380 Gen11 server utilizes the HPE Silicon Root of Trust, HPE’s fundamental approach to security that provides zero-trust architecture at the silicon level and ensures all server essential firmware is free from malware or compromised code.
- The server, powered by 4th and 5th Gen Intel ® Xeon ® Scalable Processors, adds hardware and software-assisted security features, including Intel ® Software Guard Extensions and Intel ® Boot Guard, which secure the server hardware foundation on which critical apps run and better protect data in memory.
- HPE ProLiant Gen11 servers continuously protect healthy servers by providing rapid detection of security-compromised servers, even to the point of not allowing them to boot if it identifies and contains malicious code, and secure servers at the edge with IDevID certificates installed by default.
- HPE ProLiant servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of operating system, application and data connections, providing the fastest path to bring a server back online and into normal operations.
- From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Gen11 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements that are built into our DNA.
Optimized Performance for your Workloads: Accelerated, Open, and Efficient
- The HPE ProLiant DL380 Gen11 server is an excellent choice for compute and data storage demanding workloads (AI, ML, telco, DB analytics, VDI, containers) requiring maximum core count, GPU capabilities, and network and I/O bandwidth.
- Harness major computer performance. The HPE ProLiant DL380 Gen11 server is powered by 4th and 5th Gen Intel ® Xeon ® Scalable Processors with next-generation technology that supports up to 64 cores per processor, 350W, and up to 8 TB of memory.
- The HPE ProLiant DL380 Gen11 server provides advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 2 x16 PCIe Gen5 and 2 OCP slots to improve I/O throughput and reduce latency.
- It provides 16 DIMM channels per processor for up to 8 TB total DDR5 memory with increased memory bandwidth and performance, and lower power requirements.
- It provides real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs.
Available in an As-a-Service Experience
- The HPE ProLiant DL380 Gen11 server is supported by HPE GreenLake to simplify IT infrastructure management across your entire hybrid estate. With 24x7 monitoring and management, our experts do the heavy lifting to manage your environment with services built into consumption-based solutions.
- Hewlett Packard Enterprise provides customers with choices in how they acquire and consume IT beyond traditional financing and leasing, offering options that free trapped capital, accelerate infrastructure updates, and provide on-premises pay-per-use consumption with HPE GreenLake.

